The full scientific papers that have resulted from CATCH research are listed below for you. The articles are listed based on the year in which they were published and with the name of the article. They are listed in a typical scientific format, with the authors listed first, followed by the title of the article, and followed by information about which journal it is published in, the year, issue number of the journal and page numbers. At the end of each listing there is a link to the website where the article can be read and downloaded. In all but a few cases the articles are available free of charge.


Early Rheumatoid Arthritis (ERA) Trials have almost no Generalizability to ERA patients: Results from a Large Multi-center Cohort

The CATCH researchers wanted to see how many patients with early rheumatoid arthritis (ERA) would be eligible to participate in a clinical trial. The researchers reviewed the inclusion and exclusion criteria to be a participant in certain types of RA clinical trials. These criteria are conditions that patients have to meet in order to be in a clinical trial. This information was compared to patients in CATCH, to see how many CATCH patients would have been able to participate in those trials. About one-third of CATCH patients would not be able to be in a clinical trial because they were already taking medication to treat their RA. The researchers suggest that people planning ERA clinical trials change criteria for those clinical trials so that more patients can participate, and so that they are more reflective of the real world where patients will already be taking some medications.

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What was the study purpose?
The CATCH researchers wanted to see if clinical trial data is applicable to ERA and real world patients, so they looked to see how many CATCH patients would be able to take part in clinical trials.

How was the study done?
The researchers reviewed the inclusion and exclusion criteria to participate in certain types of RA clinical trials that were publicly known. These criteria are conditions that patients must meet to be in a clinical trial. This information was compared to patients in CATCH, to see how many CATCH patients would have been eligible to be in those trials.

What were the study results?
The CATCH researchers found 44 clinical trials, and of those clinical trials, 36 were for drug treatments and 8 were to observe behavior changes. When they looked to see how many CATCH patients could have been part of those clinical trials, it ranged from between 1% to 52%. Most patients were not eligible because of some of the measures of their blood markers because they were already on medication for their RA.

This study showed a disconnect- that clinical trials are not allowing patients to participate even though those patients will likely eventually be taking those drugs. Most CATCH participants could not be in ERA clinical trials because they were already on early therapy. The CATCH researchers suggest that those people who plan trials in ERA change the criteria to be in the clinical trials so that more patients could be in them and benefit from these.